System 16 emula in maniera abbastanza buona gli arcade board (16/18) Sega Master System, Out Run, Space Harrier e Hang-On. Ecco una lista di giochi supportati da questo emulatore: Alex kidd, Alien Syndrome, Altered Beast, Aurail, Body Slam, Dynamite Dux, E-Swat, Fantazy Zone, Flashing Point, Golden Axe, Passing Shot, Quartet II, Riot City, S.D.I, Shinobi, Tetris, Time Scanner, Tough Turf, Wonderboy III, Wrestle War, Alien Storm, Moonwalker, Shadow Dancer, Hang-On, Out Run, Space Harrier, Super Hang-On.